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Archive for February, 2010

Treatment of Arthritis and Other Rheumatic Diseases

27 Feb

 Treatment of Arthritis and Other Rheumatic Diseases
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Dr. Paget himself has battled tendonitis and gout

Rheumatic diseases are characterized by inflammation (signs are redness and/or heat, swelling, and pain) and loss of function. Common symptoms of rheumatic diseases include pain, swelling, and stiffness. They especially affect joints, tendons, ligaments, bones, and muscles, although some rheumatic diseases can also involve internal organs. An estimated 43 million people in the United States have arthritis or other rheumatic conditions; they are the leading cause of disability among adults age 65 and older.
Many people use the word "arthritis" to refer to all rheumatic diseases. However, the word literally means joint inflammation. There are more than 100 rheumatic diseases, and the many different kinds of arthritis are just a portion of the rheumatic diseases.
Osteoarthritis is the most common type of arthritis, affecting an estimated 21 million adults in the United States. When people talk about "arthritis," they are usually referring osteoarthritis. Osteoarthritis primarily affects cartilage, which is the tissue that cushions the ends of bones within the joint. The cartilage begins to fray and may entirely wear away. Osteoarthritis can cause joint pain and stiffness. Disability results most often when the disease affects the spine and the weight-bearing joints (the knees and hips).
Causes of Rheumatic Disease
Scientists are studying risk factors that increase the likelihood of developing a rheumatic disease. Some of these factors have been identified. For example, in osteoarthritis, inherited cartilage weakness or excessive stress on the joint from repeated injury may play a role. In other types of arthritis, a combination of genetic factors and environmental triggers are believed to be important. Gender is another factor in some rheumatic diseases.
Arthritis Symptoms
Different types of arthritis have different symptoms. In general, people who have arthritis feel pain and stiffness in the joints. Some of the more common symptoms include:
    * Swelling in one or more joints
    * Stiffness around the joints that lasts for at least 1 hour in the early morning
    * Constant or recurring pain or tenderness in a joint
    * Difficulty using or moving a joint normally
    * Warmth and redness in a joint
Early diagnosis and treatment help decrease further joint damage and help control symptoms of arthritis and many other rheumatic diseases.
Diagnosing Rheumatic Diseases
Diagnosing rheumatic diseases can be difficult because some symptoms and signs are common to many different diseases. A general practitioner or family doctor may be able to evaluate patients or refer them to a rheumatologist (a doctor who specializes in treating arthritis and other rheumatic diseases).
The doctor will review the patient’s medical history, conduct a physical examination, and obtain laboratory tests and x rays or other imaging tests. The doctor might need to see the patient more than once to make an accurate diagnosis.
It is vital for people with joint pain to give the doctor a complete medical history. Answers to the following questions will help the doctor make an accurate diagnosis:
    * Is the pain in one or more joints?
    * When does the pain occur?
    * How long does the pain last?
    * When did you first notice the pain?
    * What were you doing when you first noticed the pain?
    * Does activity make the pain better or worse?
    * Have you had any illnesses or accidents that may account for the pain?
    * Is there a family history of any arthritis or other rheumatic disease?
    * What medicine(s) are you taking?
The doctor will examine the patient’s joints for redness, warmth, damage, ease of movement, and tenderness. To see what the joint looks like inside, the doctor might order x-rays or other imaging procedures. X rays provide an image of the bones, but they do not show cartilage, muscles, and ligaments. Other noninvasive imaging methods such as computed tomography (CT or CAT scan), magnetic resonance imaging (MRI), and arthrography show the whole joint.
The doctor may look for damage to a joint by using an arthroscope, a small, flexible tube which is inserted through a small incision at the joint and which transmits the image of the inside of a joint to a video screen.
Because some forms of arthritis can affect other organs, a complete physical examination that includes the heart, lungs, abdomen, nervous system, eyes, ears, and throat may be necessary. The doctor may order some laboratory tests to help confirm a diagnosis.
Treatments
Treatments for rheumatic diseases include rest and relaxation, exercise, proper diet, medication, and instruction about the proper use of joints and ways to conserve energy. Other treatments include the use of pain relief methods and assistive devices such as splints or braces. In severe cases, surgery could be necessary. The doctor and the patient work together to develop a treatment plan, which usually combines several types of treatment.
Rest, Exercise, and Diet
One sign of many rheumatic conditions is fatigue. People who have a rheumatic disease should develop a comfortable balance between rest and activity. For example, when experiencing pain or fatigue, it is important to take a break and rest. Too much rest, however, might cause muscles and joints to become stiff.
People with a rheumatic disease such as arthritis can participate in a variety of sports and exercise programs. Physical exercise can reduce joint pain and stiffness and increase flexibility, muscle strength, and endurance. It also helps with weight reduction and contributes to an improved sense of well-being. Before starting any exercise program, people with arthritis should talk with their doctor. Exercises that doctors often recommend include:
    * Range-of-motion exercises (e.g., stretching, dance) to help maintain normal joint movement, maintain or increase flexibility, and relieve stiffness.
    * Strengthening exercises (e.g., weight lifting) to maintain or increase muscle strength. Strong muscles help support and protect joints affected by arthritis.
    * Aerobic or endurance exercises (e.g., walking, bicycle riding) to improve cardiovascular fitness, help control weight, and improve overall well-being. Studies show that aerobic exercise can also reduce inflammation in some joints.
Another important part of a treatment program is a well-balanced diet. Along with exercise, a well-balanced diet helps people manage their body weight and stay healthy. Weight control is important to people who have arthritis because extra weight puts extra pressure on some joints and can aggravate many types of arthritis.
Medications
A variety of medications are used to treat rheumatic diseases. The type of medication depends on the rheumatic disease and on the individual patient. The medications used to treat most rheumatic diseases do not provide a cure, but rather limit the symptoms of the disease.
Medications commonly used to treat rheumatic diseases provide relief from pain and inflammation. In some cases, the medication may slow the course of the disease and prevent further damage to joints or other parts of the body.
Pain relievers such as acetaminophen (e.g., Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (e.g., Advil) are used to reduce the pain caused by many rheumatic conditions. NSAIDs have the added benefit of decreasing the inflammation associated with arthritis. A common side effect of NSAIDs is stomach irritation, which can often be reduced by changing the dosage or medication. Newer NSAIDs have been introduced to reduce gastrointestinal side effects and offer additional options for treatment.
Hyaluronic acid products like Hyalgan and Synvisc mimic a naturally occurring body substance that lubricates the knee joint. They are usually injected directly into the joint to help provide temporary relief of pain and flexible joint movement.
Heat and Cold
Heat and cold can both be used to reduce the pain and inflammation of arthritis.
Heat therapy increases blood flow, tolerance for pain, and flexibility. Physical therapists are needed for some of these therapies, such as microwave or ultrasound therapy, but patients can apply moist heat themselves by placing warm towels or hot packs on the inflamed joint or taking a warm bath or shower.
Cold therapy numbs the nerves around the joint (which reduces pain) and may relieve inflammation and muscle spasms. Cold therapy can involve cold packs, ice massage, soaking in cold water, or over-the-counter sprays and ointments that cool the skin and joints.
Capsaicin cream is a preparation put on the skin to relieve joint or muscle pain when only one or two joints are involved.
Hydrotherapy, Mobilization Therapy, and Relaxation Therapy
Hydrotherapy involves exercising or relaxing in warm water. The water takes some weight off painful joints, making it easier to exercise. It helps relax tense muscles and relieve pain.
Mobilization therapies include traction (gentle, steady pulling), massage, and manipulation. (Someone other than the patient moves stiff joints through their normal range of motion.) When done by a trained professional, these methods can help control pain, increase joint motion, and improve muscle and tendon flexibility.
Relaxation therapy helps reduce pain by teaching people various ways to release muscle tension throughout the body. Doctors and physical therapists can teach patients a variety of relaxation techniques.
Assistive Devices
The most common assistive devices for treating arthritis pain are splints and braces, which are used to support weakened joints or allow them to rest. Some of these devices prevent the joint from moving; others allow some movement. A splint or brace should be used only when recommended by a doctor or therapist, who will show the patient the correct way to put the device on, ensure that it fits properly, and explain when and for how long it should be worn. Incorrect use of a splint or brace can cause joint damage, stiffness, and pain.
A person with arthritis can use other kinds of devices to ease the pain. For example, the use of a cane when walking can reduce some of the weight placed on a knee or hip affected by arthritis. A shoe insert (orthotic) can ease the pain of walking caused by arthritis of the foot or knee. Other devices can help with activities such as opening jars, closing zippers, and holding pencils.
Surgery
In some cases, surgery might be required to repair damage to a joint after injury or to restore function or relieve pain in a joint damaged by arthritis. The doctor may recommend arthroscopic surgery, bone fusion, or arthroplasty (also known as total joint replacement, in which the damaged joint is removed and replaced with an artificial one).
Nutritional Supplements and Alternative Treatments
Nutritional supplements are often reported as helpful in treating rheumatic diseases. These include products such as S-adenosylmethionine (SAM-e) for osteoarthritis and fibromyalgia, dehydroepiandrosterone (DHEA) for lupus, and glucosamine and chondroitin sulfate for osteoarthritis. Reports on the safety and effectiveness of these products should be viewed with caution since very few claims have been carefully evaluated.
At this time, the only type of arthritis that can be cured is that caused by infections. Although symptoms of other types of arthritis can be effectively managed with rest, exercise, and medication, there are no cures. Some people claim to have been cured by treatment with herbs, oils, chemicals, special diets, radiation, or other products. However, there is no scientific evidence that such treatments cure arthritis. Moreover, some may lead to serious side effects. Patients should talk to their doctor before using any therapy that has not been prescribed or recommended by the health care team caring for the patient.
Limiting Your Pain
Changes in the home may help a person with chronic arthritis continue to live safely, productively, and with less pain. People with arthritis may become weak, lose their balance, or fall. In the bathroom, installing grab bars in the tub or shower and by the toilet, placing a secure seat in the tub, and raising the height of the toilet seat can help. Special kitchen utensils can accommodate hands affected by arthritis to make meal preparation easier. An occupational therapist can help people who have rheumatic conditions identify and make adjustments in their homes to create a safer, more comfortable, and more efficient environment.
The role you play in planning your treatment is very important. It is vital for you to have a good relationship with your doctor in order to work together. You should not be afraid to ask questions about your condition or treatment. You must understand the treatment plan and tell the doctor whether or not it is helping you. Research has shown that patients who are well informed and participate actively in their own care experience less pain and make fewer visits to the doctor.
Arnold Hakers writes for <a href="http://www.arthritison.nethttp://www.arthritison.net">http://www.arthritison.net</a> where you can find out more about <a href="wheel”>http://www.arthritison.net">wheel chairs and other topics</a>.

 

How to Treat and Prevent Muscle and Joint Pain

24 Feb

October 12th 2009 - World Arthritis Day

Pain in the muscles and joints is frequently termed arthritis by patients and sometimes by doctors, but most arthritis is not arthritis at all. True arthritis affects the joints, and the joints are red, warm, swollen, and painful to move. Arthralgia means pain without inflammation in the joints. Myalgia means pain in the muscles. these pains are not arthritis but can be very bothersome. Usually they are not serious and will go away. They can be caused by tension, virus infections, unusual exertion, accidents, or they can have no obvious cause. Only seldom do they indicate a serious disease.

There are over 100 types of arthritis and rheumatism. The four most common types are osteoarthritis, rheumatoid arthritis, gout, and spondylitis. Osteoarthritis is usually not serious, occurs in later life, and frequently causes knobby swelling of the end joints of the fingers. Rheumatoid arthritis usually starts in middle or later life and may cause you to feel sick and stiff all over in addition to the joint problems. Gout occurs mostly in men, with sudden, severe attacks of pain and swelling, usually in one joint at a time-frequently the big toe, the ankle, or the knee. Spondylitis affects the back and joints of the low back and may be suspected if your back is sore for a long time, particularly stiff in the morning, and you are unable to touch your toes.

Arthralgia and myalgia syndromes are much more common than true arthritis. Doctors often do not agree on diagnostic terms in this area, and two doctors may give different names to your problem. Arthralgia and myalgia seldom progress to a serious condition. the consequences of arthritis occur very slowly and are often better prevented than corrected. Arthritis, arthralgia, and myalgia result in more lost work days due to sickness than any other category of disease.

Only rarely does a patient with arthritis or arthralgia need to be seen by a physician immediately. Home treatment will usually resolve the problem. The relative emergencies are: (1) infection, (2) nerve damage, (3) fractures near a joint, and (4) gout. In the first three, serious damage may result if the joint is neglected; and in the fourth, the pain is so intense that immediate help is needed. Fever, weight loss, or other symptoms besides pain, or pain persisting for six weeks or more indicates the need to see the doctor if there is no obvious minor cause for these symptoms.

Both rest and exercise are important in treating muscle and joint pain. Try to relax and gently stretch the involved areas. Warm baths, massage, and stretching exercises should be used as frequently as possible. Sponge-soled shoes may help if you walk or stand on hard floors. Better light to help you relax a bit farther from the page or a better chair may help if you spend a lot of time at a desk. Regular exercise, slowly increased from every gentle move to more vigorous, can help restore the proper muscle tone; I recommend walking, bicycling, and swimming. Aspirin and ibuprofen are available over the counter and may be used in low to moderate doses. You can significantly reduce the chance of muscle and joint pain with these treatments.

 

Osteoarthritis: Are Stem Cells Really the Answer?

16 Feb

Osteoarthritis (OA) is the most common form of arthritis. It is characterized by degeneration of the articular cartilage (the gristle that caps the end of long bones in a joint) and, ultimately, joint destruction. OA is a major cause of disability in older adults and the prevalence of the condition is expected to increase over the next 20 years with the graying of the population. In fact, it has been estimated that more than 100, 000o Americans cannot transfer from their bed to the bathroom as a result of osteoarthritis of the hip or knee.

The burden of OA is made worse by the inadequacies of current therapies.

Non drug and various drug treatments are used for early OA, but protection of articular cartilage has so far not been available. Surgical intervention- meaning joint replacement- is often indicated when the symptoms cannot be controlled and the disease progresses.

Because this is such a significant public health problem- ranking among the top ten diseases chronic diseases impacting society- it has been an attractive target for researchers as well as clinicians specializing in arthritis.

A potentially valuable tool has been multipotent adult mesenchymal stem cells (MSCs), obtained from the bone marrow of normal adults. Many strategies have been studied and developed to possibly harness the ability of MSCs to differentiate into cartilage cells.

Osteoarthritis is a complicated disease. Cartilage cells, called chondrocytes, produce and secrete enzymes, such as matrix metalloproteinases and aggrecanases, which corrode cartilage.

Interleukin 1 (IL-1) is an inflammatory chemical messenger which makes these enzymes cause more damage. Stimulation of these factors leads to damage to cartilage through both reduced synthesis as well as accelerated breakdown. Other inflammatory messengers such as tumor necrosis factor are also involved in cartilage breakdown and, along with mechanical factors lead to worsening of the disease.

Despite much research into development of inhibitors of these molecules for use in treating OA, success with prevention of cartilage breakdown or with cartilage restoration has not been achieved.

That is why MSCs have been attractive. MSCs are cells that can be stimulated to differentiate along specific pathways, including cartilage production. In contrast to existing cartilage tissue which needs to be surgically harvested from non-weight-bearing cartilage, MSCs can be harvested from bone marrow.

Some evidence exists that tissue damage in osteoarthritis is due to depletion of MSC populations.

So why havent MSCs been used for OA treatment already?

First, questions exist as to whether MSCs obtained from patient with OA differ functionally from those of healthy people.

Also, age-dependent decline in the differentiation capability of MSCs has been reported by some investigators.

However, it should be pointed out that when MSCs are harvested and concentrated properly, enough MSCs with adequate differentiation potential can be isolated from patients with OA, irrespective of their age or the cause of their disease. These results indicate that MSCs for regeneration of cartilage in patients with OA is practical as well as feasible.

How to deliver stem cells is the biggest question. Direct into the joint injection of MSCs is, technically, the simplest approach to OA therapy. Unfortunately, there is no guarantee and even less data to support the effectiveness of this approach.

Compared with direct into the joint injection, MSC application to cartilage surfaces using a scaffold offers more control. The scaffold may consist of either natural or synthetic material. (The scaffold technique is the one advocated and used at the Arthritis and Osteoporosis Center of Maryland (301) 694-5800)

Another possible approach: MSCs can be introduced with various viral vectors. This permits delivery of genes that encode proteins that could potentially reverse some of the damage in OA.

 

6 Ways To Achieve Natural Arthritis Pain Relief – Part 1

12 Feb

For more information on my designs please see my Profile!  ;D

While there are many different forms of arthritis, all types can be painful and severely affect your quality of life. As a result, there are literally millions of people suffering from arthritis looking for arthritis pain relief. Many of these people are taking strong pain medication but sometimes long term use of these drugs can lead to unwanted side effects and health problems. On the other hand, natural arthritis pain relief can have minimal or no side effects and can effectively assist arthritis sufferers in managing their symptoms. Here are 7 natural pain relief treatments that are inexpensive and easy to implement.To avoid the pain, many people suffering from arthritis tend to move less. This can exacerbate the problem because the joints will become stiffer due to less movement. A recent study from the UNC Thurston Arthritis Research Center in Chapel Hill found that an exercise routine of strengthening, balancing and stretching significantly reduced the symptoms of arthritis.2) Emu Oil3) Copper / Magnets4) Acupuncture5) Aromatherapy6) Natural SupplementsMore detailed information on natural arthritis relief is available. As you can see from this list however, there are a number of treatments you can choose from that are relatively inexpensive. Before incorporating any of these treatments in to you daily schedule, you should first consult your own doctor and an expert in the treatments field.

 

What Else Works For Osteoarthritis Of The Knee… Have You Thought Of Vitamin D?

07 Feb

Were getting close to finding an arthritis cure

Osteoarthritis (OA) of the knee affects approximately 20 million Americans. It is characterized by pain, stiffness, and sometimes swelling due to inflammation and fluid accumulation.

Knee osteoarthritis is caused by cartilage deterioration within the knee joint. Factors that increase the risk of knee osteoarthritis include being obesity, age, injury or stress to the joints. In addition genetic factors play a role since a family history of the disorder can increase the risk of developing knee osteoarthritis.

A new study has shed light on another possible risk factor for OA of the knee. Low vitamin D levels may cause greater knee pain and difficulty walking in patients with knee osteoarthritis, according to research presented recently at the American College of Rheumatology Annual Scientific Meeting in Boston, Mass held November 6-12, 2007.

Recent studies have shown that vitamin D has significant influence on proper function of the musculoskeletal and neuromuscular systems.

In a two-year trial of vitamin D supplements and their effect on progression of knee OA, researchers tested whether vitamin D deficiency at study entry was linked to pain and physical function in OA patients. Researchers studied 65 women and 35 men in their sixties who showed signs of having knee OA by measuring blood levels of vitamin D, their baseline knee pain, the time needed for getting up out of a chair into a standing position and then back down again repetitively, and the time needed to walk 20 meters.

Of the 100 participants, 47 percent were vitamin D deficient, with vitamin D levels below 30 ng/ml. This deficiency contributed to increased pain and difficulty walking among the participants. However, the deficiency did not affect time needed to stand and to sit repeatedly.

Vitamin D helps the absorption of calcium and phosphorus needed for bone mineralization, modeling, growth and repair. Sources of vitamin D are available in certain food sources such as fortified margarine, oily fish, liver, fortified breakfast cereals and dairy products. Sun exposure helps vitamin D to become active.

Absorption of vitamin D from food and conversion of it to the active form occurs less efficiently in elderly persons. For this reason, vitamin D supplements of 400-800 and calcium doses of 1,200 to 1,500 mg a day are recommended to prevent osteoporosis. The interesting finding from this study suggests that Vitamin D supplements may also help in arthritis treatment as well.

Tim McAlindon, MD, MPH, associate professor of medicine, division of rheumatology, Tufts New England Medical Center and an investigator in the study commented, These results suggest thatpeople with knee osteoarthritis, having a low vitamin D level is associated with more knee pain and greater functional limitation. Dr.McAlindon also added, Future results from this ongoing randomized, double-blinded, placebo-controlled clinical trial of vitamin D will help determine whether vitamin D is an effective disease-modifying intervention for knee osteoarthritis.

Currently, treatment of osteoarthritis of the knee is limited to a combination of weight control, exercise, non-steroidal anti-inflammatory drugs, local treatments (ice, heat, topical agents), glucocorticoid injections, viscosupplements (lubricants injected into the knee), arthroscopic procedures (cleaning the knee out using a small telescope), and knee replacement in patients with severe OA.

The holy grail is to develop drugs that help slow down cartilage loss and possibly even help cartilage regenerate. While this study does not prove that vitamin D does any of this, it is a ray of hope that someday, researchers will be able to discover disease modifying osteoarthritis drugs.

 

Osteoarthritis – Brief Introduction to Natural Pain Alleviation

02 Feb

2008 CreakyJoints special recognition honorees

The most effective method for osteoarthritis pain relief is any treatment that reduces inflammation. And while there are numerous natural treatments and herbs which can do that, it’s important to learn which ones work for you. The best part? Many of these natural treatments have little or no side effects.

If you want to know more about natural and herbal osteoarthritis pain relief, then read on.

Boswellia Tree Extract

Boswellia is a powerful anti-inflammatory agent that has been clinically tested on humans. Not only can this plant derivative reduce inflammation, but it will also help with circulation. That increased circulation can take pressure off joints and improve blood flow.

Celadrin

Though it’s made from all-natural ingredients, Celadrin is actually a patented product sold under a brand label. Their ingredients are very similar to the herbs listed here, but formulated for extra efficacy. While other arthritis treatments tend to exaggerate, Celadrin is actually a remarkable tool for pain reduction and decreasing instances of inflammation.

Chondroitin Sulphate

A steady supply of chondroitin sulphate can help to lubricate the body and its joints, therefore reducing the pain associated with osteoarthritis. By lubricating the joints, this sulphate prevents further damage to the bone caused by rubbing, and therefore reduces pain and prevents progression of the disease.

Devil’s Claw

Devil’s Claw is an effective arthritis treatment that not only reduces inflammation, but also relieves symptoms and the general pain associated with arthritis. Despite its efficacy, it has not been involved in many clinical trials. However, anecdotal evidence suggests it’s very effective.

Cat’s Claw

Cat’s claw is a powerful botanical that comes from the Amazon Peruvian rain forest. With its anti-inflammatory properties, cat’s claw is often used for treating arthritis and fibromyalgia. This herb also has a rich source of pynogenol, a powerful antioxidant and free radical scavenger.

Evening Primrose Herb

Evening primrose is used to treat a variety of inflammation problems, not just osteoarthritis. However, its oil contains something called gamma linolenic acid which helps reduce inflammation. This acid is particularly effective in treating patients with osteoarthritis and has been proven in clinical studies to be just as effective as some contemporary pharmaceutical drugs.

Ginger

Ginger is a popular herb that has a wide variety of uses and abilities. It’s often used as an anti-inflammatory and has been demonstrated to improve osteoarthritis symptoms. People taking regular doses of ginger on an ongoing basis report reduced pain, reduced swelling and improved movement and mobility.

The great thing about ginger is that the side effects are minimal, aside from a bit of burping and maybe a little bad breath. If you’re concerned about ginger breath, try scent-free ginger tablets.

The natural osteoarthritis pain relief treatments listed above are known to be safe and relatively safe from undesirable side effects. However, before you start any new type of treatment or medication, you should always consult with your physician to help ensure that the mix of any alternatives don’t produce negative consequences with prescriptions you may be taking.

 

Can Not Having Enough Vitamin D Make My Rheumatoid Arthritis Worse?

01 Feb

1956-57 AF Annual Report cover

In addition to the other health problems associated with vitamin D deficiency, there is another one. Not having enough vitamin D can make rheumatoid arthritis (and other inflammatory arthritis, possibly) symptoms worse. These findings were reported recently by researchers in the United Kingdom.

In the July issue of Arthritis and Rheumatism, Dr. Sanjeev Patel of St. Helier University Hospital, Carsholton, and colleagues note that there is evidence that vitamin D and its metabolite 25-hydroxyvitamin D (25[OH]D), in particular, may have immunomodulatory effects. (Patel A, Farragher T, Berry J, Bunn D, Silman A, Symmons D. Association between serum vitamin D metabolite levels and disease activity in patients with early inflammatory polyarthritis.of Arthritis Rheum 2007;56:2143-2149).

Metabolites are what vitamin D is converted to in the body. Conversion to different forms of the vitamin can occur in the liver or kidney. Conversion is a common process. Many drugs taken for different diseases undergo this process. In fact, often the metabolite is the active form of the medicine or vitamin. In the case of vitamin D, there are two active metabolites: 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D.

The investigators wanted to find out whether metabolites of vitamin D might have an influence on polyarthritis.

Polyarthritis means a type of arthritis that affects many joints. The prototypical form of polyarthritis is rheumatoid arthritis.

The researchers measured serum levels of 25(OH)D and 1,25- dihydroxyvitamin D (1,25[OH]2D) in 206 patients within 6 months of the onset of symptoms of their disease.

They observed an inverse relationship between baseline levels of 25(OH)D and multiple measures of disease activity. In other words, the lower the vitamin D metabolite levels were, the more symptoms a patient had.

In particular, one measure- the Health Assessment Questionnaire or HAQ- is a common measure of how a patient feels. The researchers found that at baseline, 1,25(OH)2D levels had an inverse relationship with HAQ scores. At 1 year, baseline levels of both metabolites continued to have a significant inverse association with HAQ scores.

According to Dr. Patel, “The results of this study show that vitamin D deficiency may increase rheumatoid arthritis activity. We need to study this further and see if giving vitamin D or more potent drugs with vitamin D activity can relieve symptoms of rheumatoid arthritis.”

So what is the message for you if you have rheumatoid arthritis? Make sure your rheumatologist checks your vitamin D levels routinely, particularly in the winter when vitamin D levels can plummet.

If your vitamin D levels are low, you need replacement therapy. In our practice we have noted that patients with vitamin D deficiency often have more flares than patients who have normal vitamin D levels. Vitamin D levels in our patients are monitored routinely.